Wearable electronics for non-invasive personal health monitoring require advanced multimodal sensing and seamless energy system integration. However, current platforms are hindered by insufficient energy budget, limited sensing performance, user discomfort, complex circuit architectures, and bulky device form factors. In this webinar, we present a wireless, energy-autonomous, sweat sensing system based on a wearable microgrid framework. This system integrates high-efficiency, self-voltage-regulated microgrids—comprising wearable energy harvesters (similar to electrochemical biofuel cells) and flexible rechargeable batteries—to harvest and manage energy from the body.