Discover
/
Article

Spectroscopy and Imaging with Diffusing Light

MAR 01, 1995
Diffusing near‐infrared light provides new mechanisms for clinical diagnosis of tissue structure and function.

DOI: 10.1063/1.881445

Arjun Yodh
Britton Chance

Visually opaque media are ubiquitous in nature. While some materials are opaque because they strongly absorb visible light, others, such as loam, white paint, biological tissue and milk, are opaque because photons traveling within them are predominantly scattered rather than absorbed. A vanishingly small number of photons travel straight through such substances. Instead, light is transported through these materials in a process similar to heat diffusion (figure 1).

References

  1. 1. G. Maret, P. E. Wolf, Z. Phys. B 65, 409 (1987). https://doi.org/ZPCMDN
    M. J. Stephen, Phys. Rev. B 37, 1 (1988). https://doi.org/PRBMDO
    D. J. Pine, D. A. Weitz, P. M. Chaikin, E. Herbolzheimer, Phys. Rev. Lett. 60, 1134 (1988).https://doi.org/PRLTAO

  2. 2. See, for example, A. Ishimaru, Wave Propagation and Scattering in Random Media, Academic, New York (1978).
    S. Glasstone, M. C. Edlund, The Elements of Nuclear Reactor Theory, Van Nostrand, New York (1952) chs. 5, 14.
    K. M. Case, P. F. Zweifel, Linear Transport Theory, Addison‐Wesley, Reading, Mass. (1967) ch. 8 and references therein.

  3. 3. J. R. Singer, F. A. Grunbaum, P. Kohn, J. Zubelli, Science 248, 990 (1990). https://doi.org/SCIEAS
    F. F. Jobsis, Science 198, 1264 (1977). https://doi.org/SCIEAS
    For many examples of continuous‐wave imaging with diffuse light, see work in the field of diaphanography: M. Kaneko et al., Radiat. Medicine 6, 61 (1988) and references therein.

  4. 4. M. S. Patterson, B. Chance, B. C. Wilson, Appl. Opt. 28, 2331 (1989). https://doi.org/APOPAI
    B. Chance et al., Proc. Natl. Acad. Sci. USA 85, 4971 (1988). https://doi.org/PNASA6
    D. T. Delpy, M. Cope, P. van de Zee, S. Arridge, S. Wray, J. Wyatt, Phys. Med. Biol. 33, 1433 (1988). https://doi.org/PHMBA7
    S. L. Jacques, Appl. Opt. 28, 2223 (1989). https://doi.org/APOPAI
    D. A. Benaron, D. K. Stevenson, Science 259, 1463 (1993).https://doi.org/SCIEAS

  5. 5. J. Chang, Y. Wang, R. Aronson, H. L. Graber, R. L. Barbour, in Proc. Inverse Problems in Scattering and Imaging, M. A. Fiddy, ed., SPIE, Bellingham, Wash. (1992), p. 384.

  6. 6. E. Gratton, W. Mantulin, M. J. van de Ven, J. Fishkin, M. Maris, B. Chance, in Proc. 3rd Int. Conf. Peace Through Mind/Brain Science, Y. Yamashita, ed., Hamamatsu Photonics, Hamamatsu, Japan (1990), p. 183.
    J. Fishkin, E. Gratton, J. Opt. Soc. Am. A 10, 127 (1993).https://doi.org/JOAOD6

  7. 7. J. M. Schmitt, A. Knuttel, J. R. Knutson, J. Opt. Soc. Am. A 9, 1832 (1992). https://doi.org/JOAOD6
    A. Knuttel, J. M. Schmitt, J. R. Knutson, Appl. Opt. 32, 381 (1993). https://doi.org/APOPAI
    A. Knuttel, J. M. Schmitt, R. Barnes, J. R. Knutson, Rev. Sci. Instrum. 46, 638 (1993).https://doi.org/RSINAK

  8. 8. M. A. O’Leary, D. A. Boas, B. Chance, A. G. Yodh, Phys. Rev. Lett. 69, 2658 (1992).https://doi.org/PRLTAO

  9. 9. D. A. Boas, M. A. O’Leary, B. Chance, A. G. Yodh, Phys. Rev. E 47, R2999 (1993). https://doi.org/PLEEE8
    M. A. O’Leary, D. A. Boas, B. Chance, A. G. Yodh, J. Lumin. 60–61, 281 (1994).https://doi.org/JLUMA8

  10. 10. B. J. Tromberg, L. O. Svaasand, T. T. Tsay, R. C. Haskell, Appl. Opt. 32, 607 (1993). https://doi.org/APOPAI
    E. M. Sevick, J. Lakowicz, H. Szmacinski, K. Nowacyzk, M. L. Johnson, J. Photochem. Photobiol. B 16, 169 (1992).

  11. 11. M. Takada, T. Tamura, M. Tamura, Adv. Exp. Med. Biol. 215, 301 (1987). https://doi.org/AEMBAP
    H. L. Graber, J. Chang, J. Lubowsky, R. Aronson, R. L. Barbour, in Proc. Photon Migration and Imaging in Random Media and Tissues, B. Chance, R. Alfano, eds., SPIE, Bellingham, Wash. (1993) p. 372.
    M. Kashke, H. Jess, G. Gaida, J.‐M. Kaltenbach, W. Wrobel, in Proc. Advances in Optical Imaging and Photon Migration, R. R. Alfano, ed., Opt. Soc. Am., Washington, D.C. (1994) p. 88.

  12. 12. H. S. Carslaw, J. C. Jaeger, Conduction of Heat in Solids, Oxford U.P., Oxford, England (1959).

  13. 13. D. A. Boas, M. A. O’Leary, B. Chance, A. G. Yodh, Proc. Natl. Acad. Sci. USA 91, 4887 (1994). https://doi.org/PNASA6
    For similar calculations and measurements for small objects and continuous sources, see P. N. den Outer, Th. M. Nieuwenhuizen, A. Lagendijk, J. Opt. Soc. Am. A 10, 1209 (1993).

  14. 14. M. A. O’Leary, D. A. Boas, B. Chance, A. G. Yodh, Opt. Lett. 20, 426 (1995).https://doi.org/OPLEDP

  15. 15. L. Wang, P. P. Ho, C. Liu, G. Zhang, R. R. Alfano, Science 253, 769 (1991).https://doi.org/SCIEAS

  16. 16. B. Beauvoit, H. Liu, K. Kang, P. D. Kaplan, M. Miwa, B. Chance, Cell Biophys. 23, 91 (1993). https://doi.org/CBIODE
    B. Beauvoit, S. M. Evans, T. Jenkins, E. Miller, B. Chance, to be published in Anal. Biochem.

  17. 17. M. Kohl, M. Essenpries, D. Booker, M. Cope, in Proc. Conf Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, B. Chance, R. Alfano, eds., SPIE, Bellingham, Wash. (1995).

  18. 18. S. P. Gopinath, C. S. Robertson, R. G. Grossman, B. Chance, J. Neurosurg. 79, 43 (1993).https://doi.org/JONSAC

  19. 19. C. D. Kurth, J. M. Steven, S. C. Nicolson, Anesthesiology 82, 74 (1995).https://doi.org/ANESAV

  20. 20. D. T. Delpy, S. R. Arridge, M. Cope, Adv. Exp. Med. Biol. 248, 41 (1989). https://doi.org/AEMBAP
    E. M. Sevick, B. Chance, J. Leigh, S. Nioka, M. Maris, Anal. Biochem. 195, 330 (1991).https://doi.org/ANBCA2

  21. 21. B. Chance, Z. Zhuang, C. Unah, C. Alter, L. Lipton, Proc. Natl. Acad. Sci. USA 90, 3770 (1993).https://doi.org/PNASA6

  22. 22. S. R. Arridge, in Medical Optical Tomography: Functional Imaging and Monitoring, G. Muller, ed., SPIE, Bellingham, Wash. (1993), p. 31.
    S. R. Arridge, P. van de Zee, M. Cope, D. T. Delpy, in Proc. Time‐Resolved Spectroscopy and Imaging of Tissues, B. Chance, ed., SPIE, Bellingham, Wash. (1991), p. 204.
    M. A. O’Leary, D. A. Boas, B. Chance, A. G. Yodh, in Proc. Advances in Optical Imaging and Photon Migration, R. R. Alfano, ed., Opt. Soc. Am., Washington, D.C. (1994), p. 106.
    J. C. Schotland, J. C. Haselgrove, J. S. Leigh, Appl. Opt. 32, 448 (1993).https://doi.org/APOPAI

  23. 23. A. C. Kak, M. Slaney, Principles of Computerized Tomographic Imaging, IEEE, New York (1988).

  24. 24. S. Smith, W. J. Levy, S. Carter, M. Haida, B. Chance, in Proc. Photon Migration and Imaging in Random Media and Tissues, B. Chance, R. Alfano, eds., SPIE, Bellingham, Wash. (1993), p. 511.

More about the Authors

Arjun Yodh. University of Pennsylvania, Philadelphia.

Britton Chance. University of Pennsylvania, Philadelphia.

This Content Appeared In
pt-cover_1995_03.jpeg

Volume 48, Number 3

Related content
/
Article
Technical knowledge and skills are only some of the considerations that managers have when hiring physical scientists. Soft skills, in particular communication, are also high on the list.
/
Article
Professional societies can foster a sense of belonging and offer early-career scientists opportunities to give back to their community.
/
Article
Interviews offer a glimpse of how physicists get into—and thrive in—myriad nonacademic careers.
/
Article
Research exchanges between US and Soviet scientists during the second half of the 20th century may be instructive for navigating today’s debates on scientific collaboration.

Get PT in your inbox

Physics Today - The Week in Physics

The Week in Physics" is likely a reference to the regular updates or summaries of new physics research, such as those found in publications like Physics Today from AIP Publishing or on news aggregators like Phys.org.

Physics Today - Table of Contents
Physics Today - Whitepapers & Webinars
By signing up you agree to allow AIP to send you email newsletters. You further agree to our privacy policy and terms of service.