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Stretch Genes

FEB 01, 1997
By unraveling individual DNA molecules under the microscope physicistsare learing about the elastic properties that are important to DNA’s function.
Robert H. Austin
James P. Brody
Edward C. Cox
Thomas Duke
Wayne Volkmuth

Polymers—macromolecules composed of many small molecules—are vital to life. For example, proteins provide the cell with structure and carry out its mechanical and enzymatic work. Fatty acids store energy in their bonds, and lipids form the membranes that seal off the cell’s aqueous interior from its aqueous exterior. Heredity lies in the very long polymeric strands of deoxyribonucleic acid—DNA.

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References

  1. 1. M. Doi, S. F. Edwards, The Theory of Polymer Dynamics, Oxford U.P., Oxford, England (1989). See this invaluable reference for many of the concepts discussed in this article.

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  10. 10. P.‐G. de Gennes, Scaling Concepts in Polymer Physics, Cornell U.P., Ithaca, N.Y. (1979).

  11. 11. T. T. Perkins, D. E. Smith, S. Chu, Science 264, 819 (1994).https://doi.org/SCIEAS

  12. 12. W. D. Volkmuth, R. H. Austin, Nature 358, 600 (1992). https://doi.org/NATUAS
    T. Duke, R. H. Austin, E. C. Cox, S. Chan, Electrophoresis 17, 1075 (1996).https://doi.org/ELCTDN

  13. 13. D. C. Schwartz, W. Saffran, J. Welsh, R. Hass, M. Goldenberg, C. R. Cantor, Cold Spring Harbor Symp. Quant. Biol. 47, 189 (1983).https://doi.org/CSHSAZ

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  16. 16. J. M. Schurr, S. B. Smith, Biopolymers 29, 1161 (1990).https://doi.org/BIPMAA

More about the Authors

Robert H. Austin. Princeton University, Princeton, New Jersey.

James P. Brody. University of Washington, Seattle.

Edward C. Cox. Princeton.

Thomas Duke. University of Cambridge, England.

Wayne Volkmuth. Stanford University, Stanford, California.

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This Content Appeared In
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Volume 50, Number 2

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