The urinary drop spectrometer

SEP 01, 1974

Information from the external urine stream permits early, painless diagnosis of obstructions with an optical instrument developed by an interdisciplinary group.

DOI: 10.1063/1.3128862

Gerald Aiello

Pierre Lafrance

Rogers C. Ritter

James S. Trefil

A new diagnostic instrument that can potentially affect the lives of hundreds of thousands of people has resulted from a collaboration among physicians, physicists, engineers and mathematicians. This article is the case history of the interdisciplinary study which culminated in the development of the urinary drop spectrometer, a painless instrument, now in clinical use, for the early detection of lower‐urinary‐tract abnormalities. As the name implies, this instrument analyzes the spectrum of drops into which the urinary stream breaks up. As the drop spectra carry a “memory” of the passage the fluid has traversed, their statistics may be used to map the delicate tubes of the urinary system. Figure 1 shows how the output of the spectrometer clearly distinguished output from patients suffering from two different disease conditions from each other and from that of a normal individual. We will see how these clearly distinguishable differences arise, and how they form the basis for medical diagnosis.

References

1. B. F. Clarke, R. Mielke, E. Leighton, J. Urol. 96, 417 (1966).
2. M. F. Campbell, Principles of Urology, Saunders, Philadelphia, 1957, page 101.
3. A. C. Guyton, Textbook of Medical Physiology, Saunders, Philadelphia, 1971, chapter 34.
4. G. Eckstein, The Body Has a Head, Harper and Row, New York, 1969, page 272.
5. M. F. Campbell, reference 2, page 105.
6. R. H. Flocks, Medical Times 92, 519 (1964).
7. M. F. Campbell, Urology, vol. 11, Saunders, Philadelphia, 1963, chapter 25 and references cited.
8. H. Gray, Anatomy of the Human Body, (C. M. Goss, ed.), Lea and Febiger, Philadelphia, 1954, page 1370.
9. R. C. Ritter, N. R. Zinner, A. J. Paquin, J. Urol. 91, 161 (1964).
10. N. R. Zinner, Hydrodynamics of Micturition, (F. Hinman, S. Boyarsky, J. M. Pierce, N. R. Zinner, eds.), Thomas, Springfield, Illinois, 1971, chapter 22.
11. N. R. Zinner, R. C. Ritter, R. C. Sterling, D. C. Harding, Invest. Urol. 3, 379 (1969).https://doi.org/INURAQ
12. N. R. Zinner, R. C. Ritter, A. M. Sterling, D. C. Harding, J. Urol. 101, 914 (1969).
13. J. S. Lee, Y. C. Fung, Trans. of ASME Ser. E, 37, 9 (1970).
14. J. H. Forcester, D. F. Young, J. Biomechanics, 3, 297 (1970).https://doi.org/JBMCB5
15. D. F. Young, F. Y. Tsai, J. Biomechanics 6, 395 (1973).https://doi.org/JBMCB5
16. H. S. Lew, Y. C. Fung, J. Biomechanics 3, 23 (1970).https://doi.org/JBMCB5
17. G. A. Aiello, J. S. Trefil, University of Virginia Preprint (1973).
18. Lord Rayleigh, Proc. Roy. Soc. (London) 29, 71 (1879).
19. B. J. Meister, G. F. Scheele, AICHE Journal 13, 683 (1967).https://doi.org/AICEAC
20. R. E. Phinney, Phys. Fluids 16, 193 (1973).https://doi.org/PFLDAS
21. C. Weber, Z. Angew. Math. Mech. 11, 136 (1931).https://doi.org/ZAMMAX
22. A. M. Sterling, PhD thesis, University of Washington (1969).
23. D. F. Rutland, G. J. Jameson, Chem. Eng. Science 25, 1689 (1970).https://doi.org/CESCAC
24. P. Lafrance, Phys. Fluids (to be published).
25. P. Lafrance, University of Virginia Preprint (1974).
26. P. Lafrance, G. Aiello, R. C. Ritter, J. S. Trefil, Phys. Fluids (to be published).
27. Urodynamics, (S. Boyarsky, C. W. Gottschalk, E. A. Tanagho, P. O. Zimskind, eds.), Academic, New York, 1971.
28. D. J. Griffiths, Brit. J. Urology 45, 497 (1973); https://doi.org/BJURAN
D. J. Griffiths, Med. Biol. Eng. 9, 581 (1971).https://doi.org/MBENAU

More about the Authors

Gerald Aiello. Physics Department, University of Virginia, Charlottesville.

Pierre Lafrance. Physics Department, University of Virginia, Charlottesville.

Rogers C. Ritter. Physics Department, University of Virginia, Charlottesville.

James S. Trefil. Physics Department, University of Virginia, Charlottesville.