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The Origins and Future of Nuclear Magnetic Resonance Imaging

JUN 01, 1992
What began as a curiosity of physics has become the preeminent method of diagnostic medical imaging and may displace x‐ray‐based techniques in the 21st century.
Felix W. Wehrli

During the past two decades nuclear magnetic resonance has revolutionized chemistry, biochemistry, biology and, more recently, diagnostic medicine. Nuclear magnetic resonance imaging, or mri as it is commonly called, is fundamentally different from x‐ray‐based techniques in terms of the principles of spatial encoding and mechanisms of signal and contrast generation involved. Mri has a far richer ultimate potential than any other imaging technique known today, and its technology and applications are still far from maturation, which may not occur until early in the 21st century.

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References

  1. 1. I. I. Rabi, J. R. Zacharias, S. Millman, P. Kusch, Phys. Rev. 53, 318 (1938).https://doi.org/PHRVAO

  2. 2. E. M. Purcell, H. C. Torrey, R. V. Pound, Phys. Rev. 69, 37 (1946). https://doi.org/PHRVAO
    F. Bloch, W. W. Hansen, M. Packard, Phys. Rev. 70, 474 (1946).https://doi.org/PHRVAO

  3. 3. W. G. Proctor, F. C. Yu, Phys. Rev. 77, 717 (1950). https://doi.org/PHRVAO
    W. C. Dickinson, Phys. Rev. 77, 736 (1950).https://doi.org/PHRVAO

  4. 4. R. R. Ernst, W. A. Anderson, Rev. Sci. Instrum. 37, 93 (1966).https://doi.org/RSINAK

  5. 5. I. J. Lowe, R. E. Norberg, Phys. Rev. 107, 46 (1957).https://doi.org/PHRVAO

  6. 6. P. C. Lauterbur, Nature 243, 190 (1973).https://doi.org/NATUAS

  7. 7. G. N. Hounsfield, Br. J. Radiol. 46, 1016 (1973).https://doi.org/BJRAAP

  8. 8. L. Müller, A. Kumar, R. R. Ernst, J. Chem. Phys. 63, 5490 (1975).https://doi.org/JCPSA6

  9. 9. A. Kumar, D. Welti, R. Ernst, J. Magn. Res. 18, 69 (1975).https://doi.org/JOMRA4

  10. 10. W. A. Edelstein, J. M. S. Hutchison, G. Johnson, T. Redpath, Phys. Med. Biol. 25, 751 (1980).https://doi.org/PHMBA7

  11. 11. F. W. Wehrli, J. R. MacFall, G. H. Glover, G. N. Grigsby, V. Haughton, J. Johanson, Magn. Res. Imaging 2, 3 (1984).
    I. R. Young, Br. Med. Bull. 40, 139 (1984).https://doi.org/BMBUAQ

  12. 12. R. Damadian, Science 171, 1151 (1971).https://doi.org/SCIEAS

  13. 13. A. Haase, J. Frahm, D. Matthaei, J. Magn. Res. 67, 258 (1986).https://doi.org/JOMRA4

  14. 14. P. Mansfield, J. Phys. C 10, 55 (1977).https://doi.org/JPSOAW

  15. 15. M. S. Cohen, R. M. Weisskoff, Magn. Res. Imaging 9, 1 (1991).

  16. 16. J. W. Belliveau, D. N. Kennedy, R. C. McKinstry, B. R. Buchbinder, R. M. Weisskoff, M. S. Cohen, J. M. Vevea, T. J. Brady, B. R. Rosen, Science 254, 716 (1991).https://doi.org/SCIEAS

  17. 17. Z. H. Cho, C. B. Ahn, S. C. Juh, H. K. Lee, Med. Phys. 15, 815 (1988). https://doi.org/MPHYA6
    G. P. Cofer, J. M. Brown, G. A. Johnson, J. Magn. Res. 83, 608 (1989).

  18. 18. C. L. Dumoulin, S. P. Souza, M. F. Walker, W. Wagle, Magn. Res. Med. 9, 139 (1989).

  19. 19. R. B. Moon, J. D. Richards, J. Biol. Chem. 248, 7276 (1973). https://doi.org/JBCHA3
    D. I. Hoult, Nature 252, 285 (1974).https://doi.org/NATUAS

  20. 20. For a review, see P. A. Bottomley, Radiology 170, 1 (1989).https://doi.org/RADLAX

  21. 21. J. Cox, P. J. Styles, J. Magn. Res. 40, 209 (1980). https://doi.org/JOMRA4
    T. R. Brown, P. M. Kincaid, K. Ugurbil, Proc. Natl. Acad. Sci. USA 79, 3523 (1982).https://doi.org/PNASA6

  22. 22. P. R. Luyten, A. J. H. Marien, W. Heindel, P. H. J. vanDerwen, K. Herholz, J. A. vanHollander, G. Friedmann, W.‐D. Heiss, Radiology 176, 791 (1990).https://doi.org/RADLAX

  23. 23. H. Barfuss, H. Fischer, D. Hentschel, R. Ladebeck, J. Vetter Radiology 169, 811 (1988).
    C. J. Hardy, P. A. Bottomley, P. B. Roemer, R. Redington, Magn. Res. Med. 8, 104 (1988).

  24. 24. A. W. Overhauser, Phys. Rev. 92, 411 (1953).

More about the Authors

Felix W. Wehrli. University of Pennsylvania Medical Center, Philadelphia.

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This Content Appeared In
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Volume 45, Number 6

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