Scanning Force Microscopy in Biology

DEC 01, 1995

A high‐resolution instrument that can operate in liquids is making complex biological structures accessible to study in conditions close to those that exist in living organisms.

DOI: 10.1063/1.881478

Carlos Bustamante

David Keller

Microscopes have played a fundamental role in the development of biology as an experimental science. It was Robert Hooke who, when using a compound microscope in 1655, noticed that thin slices of cork were made up of identical and small self‐contained units, which he called “cells.” The generalization of this observation and its acceptance, though, had to wait until the late 1830s, when German microscopists Matthias Schleiden and Thcodor Schwann—working independently—introduced the “cell theory” of complex organisms. By the second half of the 19th century Magnus Retzius, Santiago Ramón y Cajal and Camillo Golgi were busy completing the microscopic anatomical description of the cell.

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More about the Authors

Carlos Bustamante. Howard Hughes Medical Institute, Institute of Molecular Biology, University of Oregon, Eugene.

David Keller. University of New Mexico, Albuquerque.