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Photonuclear reactions in medicine

APR 01, 1974
This technique produces useful radioisotopes of several medically important elements and has unique advantages in activation analysis of biological samples.

DOI: 10.1063/1.3128536

K. G. McNeill

Medical researchers use radioactivity in two general and important ways. First of all, they require radioactive isotopes as tags or tracers to study complex bodily processes such as the excretion of copper from the human system or the preferential uptake of isotopes by tumors. Secondly, researchers may induce radioactivity in a given biological sample in order to perform a quantitative analysis on it. This technique of activation analysis enables them to measure, for example, the amount of lead in hair and bone or to perform a multielemental analysis of blood.

References

  1. 1. Proc. Int’l Conf. on Photonuclear Reactions and Applications, Asilomar, Calif., 1973 (B. L. Berman, ed.), published by Lawrence Livermore Laboratory, Livermore, Calif.

  2. 2. C. J. Karzmark, N. C. Pering, Phys. Med. Biol. 18, 321 (1973).https://doi.org/PHMBA7

  3. 3. W. Paul, Annual Report of University of Toronto Linac Lab (1969).

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    For recent work with Cu 67, see for instance C. Raynaud, D. Comar et al., J. Nucl. Med. 14, 947, (1973).https://doi.org/JNMEAQ

  5. 5. R. O. Smith, K. R. Bennett, P. H. Lehan, H. K. Hellems, J. Nucl. Med. 14, 638 (1973). https://doi.org/JNMEAQ
    Studies with dogs have also been carried out by B. L. Holman, P. Eldh, D. F. Adams, M. H. Han, J. K. Poggenburg, S. J. Adelstein, J. Nucl. Med. 14, 274 (1973).https://doi.org/JNMEAQ

  6. 6. F. C. Gray, C. M. Cole, G. M. Meaburn, G. Brunhart, J. Nucl. Med. 14, 931, (1973).https://doi.org/JNMEAQ

  7. 7. D. E. Bryan, V. P. Guinn, D. M. Settle, Report CA 7041 General Atomic Division, General Dynamics Corporation, San Diego, (1966).

  8. 8. A. Chattopadhyay, R. E. Jervis, Radiochem. Radioanal. Letters 11, 331, (1972).https://doi.org/RRALAZ

  9. 9. G. H. Anderson, F. M. Graber, V. P. Guinn, H. R. Lukens, D. M. Settle, “Nuclear Activation Techniques in the Life Sciences,” in Proceedings of a Symposium, Amsterdam, IAEA Vienna (1967), page 99.

  10. 10. J. S. Hislop, D. R. Williams, “The Use of Non‐Destructive Gamma Activation for the Analysis of Rock and Biological Material,” AERE‐R6910. H. M. Stationery Office, London (1971).

  11. 11. R. D. Cooper, D. M. Linekin, G. L. Brownell, “Nuclear Activation Techniques in the Life Sciences,” in Proceedings of a Symposium, Amsterdam, IAEA Vienna (1967), page 65.

  12. 12. T. Asai, Y. Iwai, R. Miki, Y. Kondo, V. Sato, T. Azuma, Ann. Rep. Radiat. Centre Osaka Prefect 8, 120 (1967).

  13. 13. D. M. Settle, Proceedings 1st Int. Conf. on Forensic Activation Analysis, San Diego, 1966 (V. P. Guinn, ed.) Gulf General Atomic, Ga 8171 (1967).

  14. 14. K. M. Murray, Proc. Asilomar Conf., page 1005 and NRL Report 2581 (1973), page 10.

  15. 15. K. G. McNeill, B. J. Thomas, W. C. Sturtridge, Joan E. Harrison, J. Nucl. Med. 14, 502 (1973).https://doi.org/JNMEAQ

  16. 16. J. E. E. Baglin, B. M. Spicer, Nucl. Phys. 54, 549 (1966).https://doi.org/NUPHA7

  17. 17. A. Veres, I. Parlicsek, J. Radioanal. Chem. 3, 25 (1969).https://doi.org/JRACBN

  18. 18. A. Veres, J. Radioanal. Chem. (1973, to be published).

  19. 19. C. Engelmann, D. Y. Jerome, EUR 3896 d‐f‐e Bruxelles (1968).
    Quoted in Proc. Asilomar Conf., page 1144, (1973).

More about the Authors

K. G. McNeill. University of Toronto's Clinical Science Division.

This Content Appeared In
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Volume 27, Number 4

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