/
Article

Ion channels in nerve membranes

OCT 01, 1976
The membranes of nerves, which play a key role in the conduction of impulses, are now believed to be traversed by protein channels with ion pathways opened and closed by the membrane electric field.
Gerald Ehrenstein

The molecular mechanisms underlying the message‐carrying ability of nerves are not well understood. However, the experimental opportunities offered by the large‐diameter “giant” nerve fibers of squid (see cover photo) and certain marine worms (see figure 1) have led to the discovery of significant facts about the origin of the nerve impulse.

This article is only available in PDF format

References

  1. 1. A. L. Hodgkin, The Conduction of the Nervous Impulse, Charles C. Thomas, Springfield, Ill. (1964);
    B. Katz, Nerve, Muscle and Synapse, McGraw‐Hill, New York (1966);
    K. S. Cole, Membranes, Ions and Impulses, California U.P., Berkeley (1968);
    Biophysics and Physiology of Excitable Membranes (W. J. Adelman Jr, ed.) Van Nostrand, New York (1971).

  2. 2. G. Ehrenstein, H. Lecar, Ann. Rev. Biophys. Bioeng. 1, 347 (1972);
    R. E. Taylor, Ann. Rev. Phys. Chem. 25, 387 (1974); https://doi.org/ARPLAP
    C. M. Armstrong, Quart. Rev. Biophys. 7, 179 (1974).https://doi.org/QRBIAK

  3. 3. R. FitzHugh, in Biological Engineering (H. P. Schwan, ed.), McGraw‐Hill, New York, (1969), page 1.

  4. 4. S. McLaughlin, M. Eisenberg, Ann. Rev. Biophys. Bioeng. 4, 335 (1975).

  5. 5. G. Ehrenstein, H. Lecar, R. Nossal, J. Gen. Physiol. 55, 119 (1970); https://doi.org/JGPLAD
    M. Eisenberg, J. E. Hall, C. A. Mead, J. Membrane Biol. 14, 143 (1973); https://doi.org/JMBBBO
    S. B. Hladky, D. A. Haydon, Nature 225, 451 (1970).https://doi.org/NATUAS

  6. 6. F. Conti, L. J. DeFelice, E. Wanke, J. Physiol. 248, 45 (1975).

  7. 7. C. M. Armstrong, F. Bezanilla, Nature 242, 459 (1973).https://doi.org/NATUAS

  8. 8. A. L. Hodgkin, R. D. Keynes, J. Physiol. 128, 61 (1955).

  9. 9. T. Begenisich, J. Gen. Physiol. 66, 47 (1975).https://doi.org/JGPLAD

  10. 10. R. Henderson, J. M. Ritchie, G. R. Strichartz, Proc. Nat. Acad. Sci. US 71, 3936 (1974).

  11. 11. B. Hille, J. Gen. Physiol. 58, 599 (1971).https://doi.org/JGPLAD

  12. 12. L. Goldman, C. L. Schauf, J. Gen. Physiol. 61, 361 (1973).https://doi.org/JGPLAD

More about the authors

Gerald Ehrenstein, Molecular Biophysics, Laboratory of Biophysics, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda.

Related content
/
Article
Since 2008, more than 100 colleges and universities in the US have stopped offering an undergraduate physics major. What happened?
/
Article
The thermodynamic and quantum mechanical properties of topological insulators provide a path toward scalable energy storage in information-based batteries.
/
Article
At the end of the turbulent 1960s, the postwar funding boom in US physics came to a crashing halt. The lessons learned then may be helpful to today’s physicists.
/
Article
Interviews with 22 successful early-career physical scientists and engineers reveal that networking has been one of the most critical ways to nurture their careers.
This Content Appeared In
pt-cover_1976_10.jpeg

Volume 29, Number 10

Get PT newsletters in your inbox

pt_newsletter_card_blue.png
PT The Week in Physics

A collection of PT's content from the previous week delivered every Monday.

pt_newsletter_card_darkblue.png
PT New Issue Alert

Be notified about the new issue with links to highlights and the full TOC.

pt_newsletter_card_pink.png
PT Webinars & White Papers

The latest webinars, white papers and other informational resources.

By signing up you agree to allow AIP to send you email newsletters. You further agree to our privacy policy and terms of service.